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Heart Attack in Women

Do women have to worry about having a heart attack?

Yes. Heart disease, the cause of most heart attacks, is the #1 killer of both men and women in the US. 19 About 3 million US women have had a heart attack.20 In 2004, 345,000 women suffered a new or recurrent heart attack.20 However, women develop heart disease later than men due to the protective effects of female hormones before menopause. For women, the average age of first heart attack is 70 years, 21 about 5 years older than the average for men (66 years).

Lifetime Risk of Developing
Heart Disease22
Age Men Women
After age 40 49% 32%
At age 70 35% 24%

Even though heart disease is more common in older women, more than 9,000 US women under 45 years of age suffer a heart attack every year. Black women develop heart disease at an earlier age than women of other races.

Are women more likely to die after a heart attack than men?

It depends. Women are more likely to die in the hospital and in the 30 days following a heart attack than men. This is largely because women are older and sicker than men by the time they have a heart attack. In the long run (from 6 months to 10 years after a heart attack), men and women are just as likely to survive their heart attacks.23-27 Older women (over age 75) generally do better than men of the same age and are less likely than men to die after a heart attack.24, 28

Heart attacks are less common in younger women (under age 50), but when they do occur, younger women are at a much higher risk of dying in the hospital than younger men. Studies have found that after a heart attack, women under age 50 are twice as likely to die in the hospital than men of the same age.24, 28 The reasons for this are not fully understood.

The risk of dying from a heart attack for both men and women has fallen significantly in recent years as treatments have improved. In 2004, 75,000 women died from a heart attack, which is equal to about 2.5% of all women living with a heart attack in their past.20 Improved treatments have lowered death rates and women in particular have benefited; most recent studies have found that the gender difference often, but not always, disappears once you account for the fact that women who have heart attacks are usually older and sicker than men.

References

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  2. Kannel WB. Silent myocardial ischemia and infarction: insights from the Framingham Study. Cardiol Clin. Nov 1986;4(4):583-591.
  3. Aguilar D, Goldhaber SZ, Gans DJ, et al. Clinically unrecognized Q-wave myocardial infarction in patients with diabetes mellitus, systemic hypertension, and nephropathy. Am J Cardiol. Aug 1 2004;94(3):337-339.
  4. Burke AP, Farb A, Malcom GT, Liang Y, Smialek J, Virmani R. Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women. Circulation. Jun 2 1998;97(21):2110-2116.
  5. Little WC, Applegate RJ. Coronary angiography before myocardial infarction: Can the culprit site be prospectively recognized? Am Heart J. 1998;136:368-370.
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  8. McSweeney JC, Crane PB. Challenging the rules: women's prodromal and acute symptoms of myocardial infarction. Res Nurs Health. Apr 2000;23(2):135-146.
  9. Goldberg RJ, O'Donnell C, Yarzebski J, Bigelow C, Savageau J, Gore JM. Sex differences in symptom presentation associated with acute myocardial infarction: a population-based perspective. Am Heart J. Aug 1998;136(2):189-195.
  10. Milner KA, Funk M, Richards S, Wilmes RM, Vaccarino V, Krumholz HM. Gender differences in symptom presentation associated with coronary heart disease. Am J Cardiol. Aug 15 1999;84(4):396-399.
  11. Goldberg R, Goff D, Cooper L, et al. Age and sex differences in presentation of symptoms among patients with acute coronary disease: the REACT Trial. Rapid Early Action for Coronary Treatment. Coron Artery Dis. Jul 2000;11(5):399-407.
  12. Boersma E, Maas AC, Deckers JW, Simoons ML. Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour. Lancet. Sep 21 1996;348(9030):771-775.
  13. Steg PG, Bonnefoy E, Chabaud S, et al. Impact of Time to Treatment on Mortality After Prehospital Fibrinolysis or Primary Angioplasty. Data From the CAPTIM Randomized Clinical Trial. Circulation. November 17, 2003 2003:01.CIR.0000103122.0000110021.F0000103122.
  14. Canto JG, Zalenski RJ, Ornato JP, et al. Use of emergency medical services in acute myocardial infarction and subsequent quality of care: observations from the National Registry of Myocardial Infarction 2. Circulation. Dec 10 2002;106(24):3018-3023.
  15. Maynard C, Weaver WD, Lambrew C, Bowlby LJ, Rogers WJ, Rubison RM. Factors influencing the time to administration of thrombolytic therapy with recombinant tissue plasminogen activator (data from the National Registry of Myocardial Infarction). Participants in the National Registry of Myocardial Infarction. Am J Cardiol. Sep 15 1995;76(8):548-552.
  16. Mosca L, Jones WK, King KB, Ouyang P, Redberg RF, Hill MN. Awareness, perception, and knowledge of heart disease risk and prevention among women in the United States. American Heart Association Women's Heart Disease and Stroke Campaign Task Force. Arch Fam Med. Jun 2000;9(6):506-515.
  17. Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients with Acute Myocardial Infarction). 2004;Available at http://www.americanheart.org/presenter.jhtml?identifier=3004562.
  18. Hennekens CH, Dyken ML, Fuster V. Aspirin as a therapeutic agent in cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation. Oct 21 1997;96(8):2751-2753.
  19. Rosamond W, Flegal K, Friday G, et al. Heart Disease and Stroke Statistics--2007 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. February 6, 2007 2007;115(5):e69-171.
  20. American Heart Association. Women and Cardiovascular Diseases - Statistics. Dallas, TX: American Heart Association; 2007.
  21. WB, Abbott RD. Incidence and prognosis of unrecognized myocardial infarction. An update on the Framingham study. N Engl J Med. Nov 1 1984;311(18):1144-1147.
  22. Lloyd-Jones DM, Larson MG, Beiser A, Levy D. Lifetime risk of developing coronary heart disease. Lancet. Jan 9 1999;353(9147):89-92.
  23. Maynard C, Every NR, Martin JS, Kudenchuk PJ, Weaver WD. Association of gender and survival in patients with acute myocardial infarction. Arch Intern Med. Jun 23 1997;157(12):1379-1384.
  24. MacIntyre K, Stewart S, Capewell S, et al. Gender and survival: a population-based study of 201,114 men and women following a first acute myocardial infarction. J Am Coll Cardiol. Sep 2001;38(3):729-735.
  25. Kostis JB, Wilson AC, O'Dowd K, et al. Sex differences in the management and long-term outcome of acute myocardial infarction. A statewide study. MIDAS Study Group. Myocardial Infarction Data Acquisition System. Circulation. Oct 1994;90(4):1715-1730.
  26. Woodfield SL, Lundergan CF, Reiner JS, et al. Gender and acute myocardial infarction: is there a different response to thrombolysis? J Am Coll Cardiol. Jan 1997;29(1):35-42.
  27. Galatius-Jensen S, Launbjerg J, Mortensen LS, Hansen JF. Sex related differences in short and long-term prognosis after acute myocardial infarction: 10 year follow up of 3073 patients in database of first Danish Verapamil Infarction Trial. Bmj. Jul 20 1996;313(7050):137-140.
  28. Vaccarino V, Parsons L, Every NR, Barron HV, Krumholz HM. Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants. N Engl J Med. Jul 22 1999;341(4):217-225.

Filed in Cardiovascular Disease > Heart Attack


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