Is it safe to have an exercise ECG test after a heart attack?
There is not enough safety information to justify exercise ECG testing in the first 2 to 3 days after a heart attack. It is safe to do a treadmill test more than 5 days after an uncomplicated heart attack, when stress testing can help determine a safe level of activity. A negative (normal) test means you have a low risk of having another heart attack. If you are unable to perform an exercise ECG, you are at a higher risk of having another heart attack or dying from heart disease.18, 19 You should also have an exercise ECG before starting cardiac rehabilitation or any type of exercise program.
Does an exercise ECG have any limitations?
A normal exercise ECG is a reliable test for ruling out heart problems in women. In terms of the print out showing the heart's electrical activity, a positive exercise ECG is less reliable for women than for men. Women are prone to false positive results—the test detects a problem, but in reality there is none. Chest pain during exercise testing is also less likely to be a sign of heart disease in women than in men. Because of these limitations, you should not be referred for invasive testing such as cardiac catheterization based on a positive exercise ECG alone. The results should be confirmed through further noninvasive testing first, such as echocardiography or a nuclear stress test.
However, the exercise ECG measures a lot more than just the print out of the heart's electrical activity. It also measures your exercise capacity, and how your blood pressure and heart rate are affected by exercise. When these factors are looked at, the exercise ECG is an excellent test for predicting your risk of having a heart attack or dying from heart disease.
References
1. Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). 2004;Available at http://www.americanheart.org/downloadable/heart/1090338315100STEMIFinalFinalforposting.pdf.
2. Gibbons RJ, Balady GJ, Timothy Bricker J, et al. ACC/AHA 2002 guideline update for exercise testing: summary article. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). J Am Coll Cardiol. 2002;40:1531-1540.
3. Morise AP, Diamond GA. Comparison of the sensitivity and specificity of exercise electrocardiography in biased and unbiased populations of men and women. Am Heart J. 1995;130:741-747.
4. Barolsky SM, Gilbert CA, Faruqui A, Nutter DO, Schlant RC. Differences in electrocardiographic response to exercise of women and men: a non-Bayesian factor. Circulation. 1979;60:1021-1027.
5. Miller TD, Roger VL, Milavetz JJ, et al. Assessment of the exercise electrocardiogram in women versus men using tomographic myocardial perfusion imaging as the reference standard. Am J Cardiol. 2001;87:868-873.
6. Alexander KP, Shaw LJ, Shaw LK, et al. Value of exercise treadmill testing in women. J Am Coll Cardiol. 1998;32:1657-1664.
7. Nishime EO, Cole CR, Blackstone EH, Pashkow FJ, Lauer MS. Heart Rate Recovery and Treadmill Exercise Score as Predictors of Mortality in Patients Referred for Exercise ECG. JAMA. 2000;284:1392-1398.
8. Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS. Heart-Rate Recovery Immediately after Exercise as a Predictor of Mortality. N Engl J Med. 1999;341:1351-1357.
9. Cole CR, Foody JM, Blackstone EH, Lauer MS. Heart Rate Recovery after Submaximal Exercise Testing as a Predictor of Mortality in a Cardiovascularly Healthy Cohort. Ann Intern Med. 2000;132:552-555.
10. Kligfield P, McCormick A, Chai A, et al. Effect of age and gender on heart rate recovery after submaximal exercise during cardiac rehabilitation in patients with angina pectoris, recent acute myocardial infarction, or coronary bypass surgery. Am J Cardiol. 2003;92:600-603.
11. Mundal R, Kjeldsen SE, Sandvik L, et al. Exercise Blood Pressure Predicts Mortality From Myocardial Infarction. Hypertension. 1996;27:324-329.
12. McHam SA, Marwick TH, Pashkow FJ, Lauer MS. Delayed systolic blood pressure recovery after graded exercise: an independent correlate of angiographic coronary disease. J Am Coll Cardiol. 1999;34:754-759.
13. Pandey DK. Exaggerated Blood Pressure Response to Exercise Predicts New-Onset Hypertension in Women: Women Take Heart Study, 1992-2001. Paper presented at: 18th Annual Scientific Meeting of the American Society of Hypertension, 2003; New York.
14. Lauer MS, Francis GS, Okin PM, et al. Impaired chronotropic response to exercise stress testing as a predictor of mortality. JAMA. 1999;281:524-529.
15. Weiner DA, Ryan TJ, Parsons L, et al. Long-term prognostic value of exercise testing in men and women from the Coronary Artery Surgery Study (CASS) registry. Am J Cardiol. 1995;75:865-870.
16. Gulati M, Pandey DK, Arnsdorf MF, et al. Exercise Capacity and the Risk of Death in Women: The St James Women Take Heart Project. Circulation. 2003;108:1554-1559.
17. Mora S, Redberg RF, Cui Y, et al. Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women: a 20-year follow-up of the lipid research clinics prevalence study. JAMA. 2003;290:1600-1607.
18. Gill JB, Cairns JA, Roberts RS, et al. Prognostic Importance of Myocardial Ischemia Detected by Ambulatory Monitoring Early after Acute Myocardial Infarction. N Engl J Med. 1996;334:65-71.
19. Safstrom K, Lindahl B, Swahn E. Risk stratification in unstable coronary artery disease--exercise test and troponin T from a gender perspective. FRISC-Study Group. Fragmin during InStability in Coronary artery disease. J Am Coll Cardiol. 2000;35:1791-1800.



